San Francisco 49ers Alex Smith Anquan Boldin Larry Fitzgerald

It must have been the water.The San Francisco 49ers are likely still feeling the hangover from the whipping they received at the hands of the Arizona Cardinals the last time they faced off, on a Sunday night in Mexico City. This time around the 49ers offense must figure out a way to protect the 4 Brett Favre White jersey
quarterback and the defense must figure out a way to slow down the Cardinals potent passing attack in order for San Francisco to have a chance at victory.In their last meeting, the 49ers allowed the Cardinals to register five sacks. This constant pressure resulted in numerous turnovers and a general lack of rhythm for the 49ers offense. This time around the offensive line, which will be without Pro Bowl center Jeremy Newberry, will have to somehow become a stout unit and prevent the Cardinals pass rush from fouling up Alex Smith's first start in over a month.Defensively, the 49ers must figure out a way to slow down the receiving tandem of Larry Fitzgerald and Anquan Boldin. These two young receivers might be the best tandem in the NFL right now. They have already combined for Vikings Brett Favre jersey
131 receptions, 11 touchdowns and nearly 2,000 receiving yards. Starting cornerbacks Derrick Johnson and Shawntae Spencer should have their hands full all afternoon long. However, if they can prevent big plays downfield and come up with a turnover or two the 49ers will be in a position to win this game.We'll find out for sure on Sunday. Kickoff is set for 1:05 pm PST.